Query: NC_008095:5585346 Myxococcus xanthus DK 1622, complete genome Lineage: Myxococcus xanthus; Myxococcus; Myxococcaceae; Myxococcales; Proteobacteria; Bacteria General Information: First isolated from soil in 1941. Bacterium with a multi-stage lifecycle. M.xanthus is a Gram-negative rod-shaped bacterium. This organism undergoes a complex development and differentiation pathway. When cell density increases, the organism switches to "social motility" where aggregates of cells can gather together into masses termed fruiting bodies that may consist of up to 100 000 cells. This organism is also utilized industrially to produce the anticancer drug epithilone.
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General Information: Source of the antibiotic erythromycin. Saccharopolyspora erythraea is the soil bacterium that produces the industrially important antibiotic erythromycin A. Erythromycin is a clinically important and potent macrolide antibiotic. It is used to treat infections caused by several prokaryotic pathogens such as Streptococcus, Staphylococcus, Mycoplasma, Ureaplasma, Chlamydia and Legionella. Production of this antibiotic is lower than others in the same class, such as penicillin or cephalosporin, which has led to the development of a genetic system to attempt to enhance the production of erythromycin.