Query: NC_008011:663958 Lawsonia intracellularis PHE/MN1-00, complete genome Lineage: Lawsonia intracellularis; Lawsonia; Desulfovibrionaceae; Desulfovibrionales; Proteobacteria; Bacteria General Information: Lawsonia intracellularis PHE/MN1-00 was isolated from intestinal mucosal lesions in pigs that had proliferative enteropathy (PE). When introduced into health pigs, this organism produced the clinical and histological signs of PE. Causative agent for proliferative enteropathy in swine. This organism causes proliferative enteropathy (ileitis) in swine and other domesticated animals resulting in severe losses each year. This obligate intracellular pathogen infects the mucosa of the lower intestinal tract by initially infecting crypt cells, which are precursors that normally grow and divide in order to replace the epithelial cells. Once infection occurs, the crypt cells are stimulated to grow and divide abnormally, resulting in the proliferative phenotype. In severe cases of the disease the entire bowel can become affected and persist for up to 40 days, greatly affecting the host animal.
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General Information: This strain was isolated from an iron-rich microbial mat from School Street Marsh in Woods Hole, MA, USA. It grows photoautotrophically with Fe(II), H2, or thiosulfate as the electron donor, photoheterotrophically with a variety of organic carbon sources and chemoheterotrophically in the dark. This organism has a diverse metabolism and is capable of growth using light, inorganic, or organic compounds as energy sources and carbon dioxide or organic compounds as carbon sources. Commonly found in soil and water environments this bacterium is also capable of degrading a wide range of toxic organic compounds, and may be of use in bioremediation of polluted sites. The bacterium undergoes differentiation to produce a stalked nonmotile cell and a motile flagellated cell. In the presence of light, this bacterium produces a number of intracellular membranous vesicles to house the photosynthetic reaction centers.