Query: NC_007963:3500468 Chromohalobacter salexigens DSM 3043, complete genome Lineage: Chromohalobacter salexigens; Chromohalobacter; Halomonadaceae; Oceanospirillales; Proteobacteria; Bacteria General Information: Chromohalobacter salexigens DSM 3043 was first isolated from a solar salt facility on Bonaire Island, Netherlands Antilles. A moderate halophile which can grow on a variety of salts. This bacterium is a moderate halophile, yet does not require high concentrations of sodium chloride. The salt requirements of this organism can be met by ions of other salts, such as potassium, rubidium, ammonium, bromide. Several plasmids have been isolated from this organism. Plasmid pMH1 contains genes for resistance to kanamycin, neomycin, and tetracycline. A smaller plasmid, pHE1, which does not code for antibiotic resistance genes, has also been isolated.
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General Information: Causes bovine brucellosis. They are highly infectious, and can be spread through contact with infected animal products or through the air, making them a potential bioterrorism agent. Once the organism has entered the body, it can become intracellular, and enter the blood and lymphatic regions, multiplying inside phagocytes before eventually causing bacteremia (spread of bacteria through the blood). Once the organism has entered the body, it can become intracellular, and enter the blood and lymphatic regions, multiplying inside phagocytes before eventually causing bacteremia (spread of bacteria through the blood). Virulence may depend on a type IV secretion system which may promote intracellular growth by secreting important effector molecules. This organism was first noticed on the island of Malta by Dr. David Bruce during an epidemic among British soldiers. It is the primary cause of bovine brucellosis, which results in enormous (billions of dollars) economic losses due primarily to reproductive failure and food losses. In man, it causes undulant fever, a long debilitating disease that is treated by protracted administration of antibiotics.