Query: NC_007951:570500 Burkholderia xenovorans LB400 chromosome 1, complete sequence Lineage: Burkholderia xenovorans; Burkholderia; Burkholderiaceae; Burkholderiales; Proteobacteria; Bacteria General Information: Originally identified as Pseudomonas sp. LB400 that was found in contaminated soil in upstate New York, USA, this organism is now classified in the genus Burkholderia. Polychlorinated biphenyl-degrading bacterium. Member of the genus Burkholderia are versatile organisms that occupy a surprisingly wide range of ecological niches. These bacteria are exploited for biocontrol, bioremediation, and plant growth promotion purposes. Burkholderia xenovorans has been found on fungi, animals, and from human clinical isolates such as from cystic fibrosis (CF) patients. It may be tightly associated with white-rot fungus, as the degadation of lignin by the fungus results in aromatic compounds the bacterium can then degrade. This organism is exceptionally capable of degradation of polychlorinated biphenyls (PCBs), which are environmental pollutants, and thus it may play a role in bioremediation of polluted and toxic sites and is studied as a model bioremediator. PCBs can be utilized as the sole carbon and energy source by this organism. The pathways for degradation of PCBs have been extensively characterized at both the genetic and the molecular level and have become a model system for the bacterial breakdown of these very persistent environmental contaminants.
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General Information: Bacteria belonging to the Pseudomonas group are common inhabitants of soil and water and can also be found on the surfaces of plants and animals. Pseudomonas bacteria are found in nature in a biofilm or in planktonic form. Pseudomonas bacteria are renowned for their metabolic versatility as they can grow under a variety of growth conditions and do not need any organic growth factors. This organism is an opportunistic human pathogen. While it rarely infects healthy individuals, immunocompromised patients, like burn victims, AIDS-, cancer- or cystic fibrosis-patients are at increased risk for infection with this environmentally versatile bacteria. It is an important soil bacterium with a complex metabolism capable of degrading polycyclic aromatic hydrocarbons, and producing interesting, biologically active secondary metabolites including quinolones, rhamnolipids, lectins, hydrogen cyanide, and phenazines. Production of these products is likely controlled by complex regulatory networks making Pseudomonas aeruginosa adaptable both to free-living and pathogenic lifestyles. The bacterium is naturally resistant to many antibiotics and disinfectants, which makes it a difficult pathogen to treat.