Pre_GI: SWBIT SVG BLASTP

Query: NC_007948:4558000 Polaromonas sp. JS666, complete genome

Lineage: Polaromonas; Polaromonas; Comamonadaceae; Burkholderiales; Proteobacteria; Bacteria

General Information: This strain was isolated from sediment contaminated with cis-dichloroethane (cDCE), a common pollutant resulting from widespread manufacture and use of industrial solvents. This bacterium is the only known organism capable of using cDCE as a sole carbon and energy source. The ability of this strain to convert ethene to epoxyethane suggests that the first step in the cDCE biodegradation pathway is the oxidation of cDCE to an epoxide compound. Bacteria that are able to grow on cDCE are rare, and have only been found in very few highly selective artificial environments. The discovery of this bacteria may provide a low cost, self-sustaining bioremediation method in areas where cDCE is a problem contaminant.

Subject: NC_013316:1 Clostridium difficile R20291, complete genome

Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile R20291 was isolated in Stoke Mandeville Hospital, UK in 2006 and is closely related to the North American hypervirulent BI strains. Clostridium difficile, a Gram-positive, spore-forming anaerobic bacterium, is the leading cause of infectious diarrhea among patients in hospitals worldwide, causing C. difficile infection (CDI). An important nosocomial pathogen, it is frequently associated with antibiotic treatment and causes diseases ranging from antibiotic-associated diarrhea to life-threatening pseudomembraneous colitis.