Query: NC_007907:2830574 Desulfitobacterium hafniense Y51, complete genome Lineage: Desulfitobacterium hafniense; Desulfitobacterium; Peptococcaceae; Clostridiales; Firmicutes; Bacteria General Information: This strain was isolated from soil contaminated with tetrachloroethene (PCE) in Japan. It can efficiently dehalogenate PCEs via trichloroethene (TCE) to cis-1,2-dichloroethene (cis-1,2-DCE). It can also dehalogenase tetra-, penta-, and hexachloroethanes. Hydrocarbon dehalogenator. This organism can dehalogenate a variety of hydrocarbons and can utilize fumarate, sulfite, and thiosulfate (but not thiousulfate) as terminal electron acceptors. Some important pollutants such as polychlorinated biphenyls (PCBs) may be degraded by this organism.
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General Information: Bartonella henselae str. Houston-1 (ATCC 49882) was isolated from human blood in Houston Texas. Causative agent of cat scratch fever. This group of alpha proteobacteria are unique among pathogens in that they cause angiogenic lesions. This organism was identified as the causative agent of cat scratch fever, a disease found commonly in children or in immunocompromised adults. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells.