Pre_GI: SWBIT SVG BLASTP

Query: NC_007798:520109 Neorickettsia sennetsu str. Miyayama, complete genome

Lineage: Neorickettsia sennetsu; Neorickettsia; Anaplasmataceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This organism was first described in 1953 in Japan as causing Sennetsu fever. Causes an infectious mononucleosis-like disease. Like other Ehrlichia, this organism is an obligate intracellular pathogen. It can be transmitted from fish flukes (trematodes) to humans, and was one of the first Ehrlichia that was found to cause a human-specific illness.

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BLASTP Alignment.txt

Subject: NC_006142:994753 Rickettsia typhi str. Wilmington, complete genome

Lineage: Rickettsia typhi; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, is composed of obligate intracellular pathogens. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. Transovarial transmission (from mother to offspring) occurs in the invertebrate host. Rickettsia typhi causes murine typhus and is an obligate intracellular pathogen that infects both the flea vector and hosts such as human, rat, and mouse. In the flea vector, the bacterium penetrates the gut epithelial barrier and is found in the feces which become infective.