Pre_GI: SWBIT SVG BLASTP

Query: NC_007797:914500 Anaplasma phagocytophilum HZ, complete genome

Lineage: Anaplasma phagocytophilum; Anaplasma; Anaplasmataceae; Rickettsiales; Proteobacteria; Bacteria

General Information: Isolated from a patient in New York, USA, in 1995. This organism is a tick-borne (Ixodesspp.) obligate intracellular pathogen that infects humans and causes human granulocytic anaplasmosis as well as infecting several other types of animals. This organism produces a number of pathogenic factors that aid virulence. These include specific adhesins for neutrophils, virulence factors that inhibit both phagosome-lysozome fusion and production of reactive oxygen species that would normally kill the bacterium. The bacterium also inhibits programmed cell death of the neutrophil (apoptosis) and induces expression of interleukin-8, which causes neutrophil chemotaxis, thereby increasing the spread of the bacterium throughout the host organism.

Subject: NC_011891:4104000 Anaeromyxobacter dehalogenans 2CP-1, complete genome

Lineage: Anaeromyxobacter dehalogenans; Anaeromyxobacter; Myxococcaceae; Myxococcales; Proteobacteria; Bacteria

General Information: This strain (2CP-1; ATCC BAA-258) is the type strain for the species and was isolated from stream sediment near Lansing, Mich., USA. This anaerobic species was originally isolated by enrichment and isolation of single plate-grown colonies, and was the first pure culture of myxobacteria able to grow anaerobically. The unique physiological characteristics of this organism include the ability to use ortho-substituted mono- and dichlorinated phenols, nitrate, H2 and fumarate as terminal electron acceptors.