Query: NC_007677:1312243 Salinibacter ruber DSM 13855, complete genome Lineage: Salinibacter ruber; Salinibacter; Rhodothermaceae; Bacteroidetes Order II; Bacteroidetes; Bacteria General Information: This organism is an extremely halophilic aerobe originally isolated from saltern crystallizer ponds in Spain. These bacteria can coexist in significant colonies with halophilic archaea under saline conditions. In contrast to other bacteria they do not regulate their intracellular salt conditions through proton pumps, but instead their protein makeup has adapted to be functional under high ionic conditions.
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General Information: This strain was isolated from a human skin biopsy in Brazil, and passaged in nude mice and armadillos. The bacterium is a close relative of M. tuberculosis. However, compared to the latter, the genome of M. leprae is smaller due to reductive genome evolution, with many important metabolic activities including siderophore production, part of the oxidative chain, most of the microaerophilic and anaerobic respiratory chains, and numerous catabolic systems and their regulatory circuits eliminated due to extensive recombination events between dispersed repetitive sequences. It is evident that this species has undergone massive genome reduction over time as a result of its parasitic nature, discarding more than half its genes and rendering it the most striking example of genome reduction in a microbial pathogen.