Query: NC_007520:2128178 Thiomicrospira crunogena XCL-2, complete genome Lineage: Thiomicrospira crunogena; Thiomicrospira; Piscirickettsiaceae; Thiotrichales; Proteobacteria; Bacteria General Information: This organism is a colorless sulfur-oxidizing bacterium isolated from a deep-sea hydrothermal vent. Sulfur-oxidizing bacterium. Thiomicrospira crunogena is a chemoautotroph commonly isolated from deep sea and shallow-water hydrothermal vents. This organism uses the oxidation of reduced sulfur compounds (thiosulfate, sulfide and sulfur) to generate the energy necessary to fix carbon and plays an important role in the cycling of sulfur in the marine environment.
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General Information: Causative agent for Rocky Mountain Spotted Fever. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.