Pre_GI: SWBIT SVG BLASTP

Query: NC_007484:1229899 Nitrosococcus oceani ATCC 19707, complete genome

Lineage: Nitrosococcus oceani; Nitrosococcus; Chromatiaceae; Chromatiales; Proteobacteria; Bacteria

General Information: Found in marine or saline environments. Ammonia-oxidizing bacterium. This species, along with Nitrosococcus halophilus, are ammonia-oxidizing bacteria found within the gamma subdivision of Proteobacteria. This organism has two surface layers, and produces a central stack of intracytoplasmic membranes (flattened vesicles).

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BLASTP Alignment.txt

Subject: NC_009727:1542000 Coxiella burnetii Dugway 7E9-12, complete genome

Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Coxiella burnetii Dugway 5J108-111 was isolated from rodents in Utah, USA. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.