Query: NC_007426:205390 Natronomonas pharaonis DSM 2160, complete genome Lineage: Natronomonas pharaonis; Natronomonas; Halobacteriaceae; Halobacteriales; Euryarchaeota; Archaea General Information: Isolated from Lake Gabara in Egypt. Extreme haloalkaliphilic archeon. Natronomonas pharaonis is able to survive at high salt and pH conditions which results in limited nitrogen availability through ammonium. In order to compensate for this, Natronomonas pharaonis has developed three systems to promote nitrogen assimilation: direct uptake of ammonia, uptake of nitrate, and uptake of urea. Another problem with high pH environments is the use of a proton gradient for the generation of ATP, which other alkaliphiles have adapted to by substitution of sodium ions for protons. However, this organism utilizes protons for ATP generation as determined by experimental data.
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General Information: Human gut bacterium. This species is a normal inhabitant of the healthy human gut. Newborns, especially those that are breast-fed, are colonized with Bifidobacteria within days after birth. This species was first isolated from the feces of a breast-fed infant. In one comprehensive 16S rDNA sequence-based enumeration of the colonic microbiota of three healthy adult humans it represents, on average, 0.008% of all 16S rDNA sequences and 4.302% of the sequences in its division (Eckburg et. They are saccharolytic organisms that produce acetic and lactic acids without generation of CO2, except during degradation of gluconate.