Pre_GI: SWBIT SVG BLASTP

Query: NC_006814:51500 Lactobacillus acidophilus NCFM, complete genome

Lineage: Lactobacillus acidophilus; Lactobacillus; Lactobacillaceae; Lactobacillales; Firmicutes; Bacteria

General Information: This organism is a normal inhabitant of the human intestinal tract. This strain was isolated from a human in 1970. Normal gastrointestinal bacterium. They are commonly found in the oral, vaginal, and intestinal regions of many animals. They are important industrial microbes that contribute to the production of cheese, yogurt, and other products such as fermented milks, all stemming from the production of lactic acid, which inhibits the growth of other organisms as well as lowering the pH of the food product. Industrial production requires the use of starter cultures, which are carefully cultivated, created, and maintained, which produce specific end products during fermentation that impart flavor to the final product, as well as contributing important metabolic reactions, such as the breakdown of milk proteins during cheese production. The end product of fermentation, lactic acid, is also being used as a starter molecule for complex organic molecule syntheses. This organism has been studied for its ability to help the human gut maintain its natural microbial community. Strains of this organism are also used in the production of yogurt, cheese and other fermented foods.

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BLASTP Alignment.txt

Subject: NC_018870:1417851 Thermacetogenium phaeum DSM 12270 chromosome, complete genome

Lineage: Thermacetogenium phaeum; Thermacetogenium; Thermoanaerobacteraceae; Thermoanaerobacterales; Firmicutes; Bacteria

General Information: Nitrogen fixation. Thermophilic strictly anaerobic bacterium oxidizing acetate to CO2 in syntrophic association with a methanogenic partner. Capable of growing with various substrates such as alcohols and methylated nitrogen compounds, and to reduce sulfate in the presence of acetate. Isolated from sludge of an anaerobic digester run at 58 degrees C. Thermacetogenium phaeum is a strictly anaerobic, homoacetogenic bacterium. It is exceptional because it can use the homoacetogenic Wood-Ljungdahl (CO- dehydrogenase) pathway both for acetate formation and acetate oxidation. Acetate oxidation is possible only in syntrophic cooperation with a methanogenic partner which maintains a low hydrogen and/or formate concentration in the coculture. With this, the bacterium operates close to the thermodynamic equilibrium of substrate conversion, similar to other syntrophically fermenting bacteria such as Syntrophomonas wolfei the genomes of which have been sequenced as well in the recent past.