Query: NC_006582:4256915 Bacillus clausii KSM-K16, complete genome Lineage: Bacillus clausii; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria General Information: Alkaliphilic strain of was isolated from soil. Alkaline-tolerant bacterium. Bacillus clausii is able to tolerate high pH levels and produces alkaline-tolerant enzymes particularly alkaline proteases. B. clausii have been isolated from soil and water. This organism has also been reported to have a beneficial effect in the human gut and is being considered for use as a probiotic.
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General Information: This strain is the first isolate of Ehrlichia chaffeensis, which was obtained from a patient on an army base in Arkansas, USA in 1990. Causes disease in humans. This organism is an obligate intracellular pathogen that exists within vacuoles in the cytoplasm of monocytes or granulocytes. Transferred during an insect (tick) bite, it can cause disease in humans (human monocytic ehrlichiosis) and can reside in several other animals and is a problem in immunocompromised patients. The bacterium inhibits phagosome-lysozome fusion as well as programmed cell death (apoptosis) of the host cell, similar to what is observed with Anaplasma phagocytophilum.