Query: NC_006371:1997954 Photobacterium profundum SS9 chromosome 2, complete sequence Lineage: Photobacterium profundum; Photobacterium; Vibrionaceae; Vibrionales; Proteobacteria; Bacteria General Information: Isolated at a depth of 2500 m from the Sulu Trough. High pressure tolerant bacterium. This bioluminescent genus was originally identified in 1878 in association with hake (a marine fish) in Cape Town, South Africa. This species was originally isolated from an amphipod homogenate enrichment from the Sulu Sea. It is a genetically tractable model system for studies of low temperature and high pressure adaptation, and has been used in studies of mono- and polyunsaturated fatty acid production under these conditions.
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General Information: This strain was isolated from an infected goat and is pathogenic in humans. Causes brucellosis and undulant fever. They are highly infectious, and can be spread through contact with infected animal products or through the air, making them a potential bioterrorism agent. Once the organism has entered the body, it can become intracellular, and enter the blood and lymphatic regions, multiplying inside phagocytes before eventually causing bacteremia (spread of bacteria through the blood). Virulence may depend on a type IV secretion system which may promote intracellular growth by secreting important effector molecules. This organism is a facultative intracellular bacteria that causes abortion in wild and domestic animals, usually goats or sheep, and undulant fever in humans. Brucellosis is a major health problem in the Mediterranean region and parts of Asia, Africa, and Latin America, where it causes severe economic losses. The disease is transmitted to humans by nonpasteurized milk and milk products or by direct contact with infected animals or carcasses.