Query: NC_006348:2738425 Burkholderia mallei ATCC 23344 chromosome 1, complete sequence Lineage: Burkholderia mallei; Burkholderia; Burkholderiaceae; Burkholderiales; Proteobacteria; Bacteria General Information: This type strain came from a Chinese patient in Burma who had glanders in 1944. Causes glanders in horses. This organism is rarely associated with human infection, and is more commonly seen in domesticated animals such as horses, donkeys, and mules where it causes glanders, a disease first described by Aristotle. The pathogen is host-adapted and is not found in the environment outside of its host. Rapid-onset pneumonia, bacteremia (spread of the organism through the blood), pustules, and death are common outcomes during infection. No vaccine exists for this potentially dangerous organism.
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General Information: This is a clinical strain isolated in 1996 in Osaka, Japan. It contains a type III secretion system which may enable colonization and penetration of the host intestinal epithelial layer, and possibly lead to septicemia. The genome contains multipe chromosomal rearrangements as compared to Vibrio cholerae. The organism also produces a hemolysin (thermostable direct hemolysin - TDH) that is particular to Vibrio parahaemolyticus. This genus is abundant in marine or freshwater environments such as estuaries, brackish ponds, or coastal areas; regions that provide an important reservoir for the organism in between outbreaks of the disease. Vibrio can affect shellfish, finfish, and other marine animals and a number of species are pathogenic for humans. This species causes food poisoning (gastroenteritis) in countries that have elevated levels of seafood consumption such as Japan.