Pre_GI: SWBIT SVG BLASTP

Query: NC_006085:1379370 Propionibacterium acnes KPA171202, complete genome

Lineage: Propionibacterium acnes; Propionibacterium; Propionibacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Isolated from human skin. Acne causing bacterium. This bacterium is the most common gram-positive, non-spore forming, anaerobic rod encountered in clinical specimens. The causative agent of acne, it typically grows as an obligate anaerobe. Some strains are aerotolerant, but still show better growth as an anaerobe. It has the ability to produce propionic acid, as its name suggests. It also has the ability to produce catalase along with indole, nitrate, or both indole and nitrate. Propionibacterium resembles Corynebacterium in morphology and arrangement, but is non-toxigenic.It is a common resident of the pilosebaceous (hair follicle) glands of the human skin. The bacteria release lipases to digest a surplus of the skin oil, sebum, that has been produced. The combination of digestive products (fatty acids) and bacterial antigens stimulates an intense local inflammation that bursts the hair follicle. Since acne is caused in part from an infection, it can be suppressed with topical and oral antibiotics such as clindamycin, erythromycin, or tetracycline. Some other forms of therapy include chemicals that enhance skin removal or slow the production of sebum.

Subject: NC_014932:1232346 Bartonella clarridgeiae 73, complete genome

Lineage: Bartonella clarridgeiae; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: Bartonella clarridgeiae was first identified from a case of cat scratch fever in a veterinarian who had been bitten by a cat. This organism has subsequently been identified in both cats and dogs. Cats, which are infected by fleas carrying the bacteria, in turn infect humans when scratching or biting them, hence the name. A small red bump forms at the site of infection, followed 2-3 weeks later by a painful swelling of the lymph node. In immunocompromized patients, more severe progress may be observed, including encephalitis, swelling of the spleen, and heart valve infection. Approximately 24 000 cases are reported in the US each year.