Pre_GI: SWBIT SVG BLASTP

Query: NC_005956:1648000 Bartonella henselae str. Houston-1, complete genome

Lineage: Bartonella henselae; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: Bartonella henselae str. Houston-1 (ATCC 49882) was isolated from human blood in Houston Texas. Causative agent of cat scratch fever. This group of alpha proteobacteria are unique among pathogens in that they cause angiogenic lesions. This organism was identified as the causative agent of cat scratch fever, a disease found commonly in children or in immunocompromised adults. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells.

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BLASTP Alignment.txt

Subject: NC_013061:987744 Pedobacter heparinus DSM 2366, complete genome

Lineage: Pedobacter heparinus; Pedobacter; Sphingobacteriaceae; Sphingobacteriales; Bacteroidetes; Bacteria

General Information: Isolation: Soil; Temp: Mesophile; Temp: 25 - 30C; Habitat: Soil. Formerly Sphingobacterium heparinum this organism was isolated from soil. This organism is able to degrade heparin and heparan sulfate glycosaminoglycans, which are components of extracellular polysaccharides and the cell surface.