Pre_GI: SWBIT SVG BLASTP

Query: NC_005956:1648000 Bartonella henselae str. Houston-1, complete genome

Lineage: Bartonella henselae; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: Bartonella henselae str. Houston-1 (ATCC 49882) was isolated from human blood in Houston Texas. Causative agent of cat scratch fever. This group of alpha proteobacteria are unique among pathogens in that they cause angiogenic lesions. This organism was identified as the causative agent of cat scratch fever, a disease found commonly in children or in immunocompromised adults. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells.

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BLASTP Alignment.txt

Subject: NC_002927:5327094 Bordetella bronchiseptica RB50, complete genome

Lineage: Bordetella bronchiseptica; Bordetella; Alcaligenaceae; Burkholderiales; Proteobacteria; Bacteria

General Information: This strain was isolated from a rabbit. Causes a respiratory illness in animals. This group of organisms is capable of invading the respiratory tract of animals and causing severe diseases. They express a number of virulence factors in order to do this including filamentous hemagglutinins for attachment, cytotoxins, and proteins that form a type III secretion system for transport of effector molecules into host cells. Bordetella bronchiseptica, which is one of the few Bordetella that is capable of persisting in the environment, is rarely found in humans and is often associated with animals. This organism cause respiratory disease most commonly in pigs, rabbits and dogs.