Query: NC_005823:1105524 Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 Lineage: Leptospira interrogans; Leptospira; Leptospiraceae; Spirochaetales; Spirochaetes; Bacteria General Information: This strain was isolated from a patient with severe leptospirosis during an epidemic in 1996. This organism is the causative agent of leptospirosis, a tropical zoonosis transmitted by direct contact with the urine of infected animals. This motile and obligately aerobic organism grows optimally at 28-30 C. Many serovars are adapted for specific mammalian reservoir hosts, which harbor the organisms in their renal tubules and shed them in their urine. Because of the large spectrum of animal species that serve as reservoirs, leptospirosis is considered to be the world's most widespread zoonotic disease.
- Sequence; - BLASTP hit: hover for score (Low score = Light, High score = Dark); - hypothetical protein; - cds: hover for description
General Information: This strain was isolated from a human in South Africa. Causative agent for Rocky Mountain spotted fever. This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, is composed of obligate intracellular pathogens. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. Transovarial transmission (from mother to offspring) occurs in the invertebrate host. This organism causes Rocky Mountain spotted fever which can cause severe damage to the endothelial layer of major organs, including the lungs, heart, kidneys, and skeletal muscle which can result in death.