Pre_GI: SWBIT SVG BLASTP

Query: NC_004193:950000 Oceanobacillus iheyensis HTE831, complete genome

Lineage: Oceanobacillus iheyensis; Oceanobacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This organism is extremely salt tolerant and alkaliphilic and has a number of hydrogen, sodium and potassium transporters to deal with these extreme environments. This organism was isolated from deep sea mud (1050 m) from the Iheya ridge near Okinawa, Japan in 1998.

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BLASTP Alignment.txt

Subject: NC_000921:1007519 Helicobacter pylori J99, complete genome

Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1994 in the USA from a patient with duodenal ulcer. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.