Query: NC_003413:128228 Pyrococcus furiosus DSM 3638, complete genome
Lineage: Pyrococcus furiosus; Pyrococcus; Thermococcaceae; Thermococcales; Euryarchaeota; Archaea
General Information: This strain was isolated from a shallow marine solfataric (volcanic area that gives off sulfuric gases) region at Vulcano Island, Italy. This organism is a strictly anaerobic, hyperthermophilic archaeon. Growth occurs at temperatures between 67 and 103 degrees C, with optimal growth at 100 degrees C and a pH of 7.0. This organism is highly motile due to a bundle of flagella.
Subject: NC_008011:663958 Lawsonia intracellularis PHE/MN1-00, complete genome
Lineage: Lawsonia intracellularis; Lawsonia; Desulfovibrionaceae; Desulfovibrionales; Proteobacteria; Bacteria
General Information: Lawsonia intracellularis PHE/MN1-00 was isolated from intestinal mucosal lesions in pigs that had proliferative enteropathy (PE). When introduced into health pigs, this organism produced the clinical and histological signs of PE. Causative agent for proliferative enteropathy in swine. This organism causes proliferative enteropathy (ileitis) in swine and other domesticated animals resulting in severe losses each year. This obligate intracellular pathogen infects the mucosa of the lower intestinal tract by initially infecting crypt cells, which are precursors that normally grow and divide in order to replace the epithelial cells. Once infection occurs, the crypt cells are stimulated to grow and divide abnormally, resulting in the proliferative phenotype. In severe cases of the disease the entire bowel can become affected and persist for up to 40 days, greatly affecting the host animal.