Pre_GI: SWBIT SVG BLASTP

Query: NC_003198:3586000 Salmonella enterica subsp. enterica serovar Typhi str. CT18,

Lineage: Salmonella enterica; Salmonella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causes enteric infections. This group of Enterobactericiae have pathogenic characteristics and are one of the most common causes of enteric infections (food poisoning) worldwide. They were named after the scientist Dr. Daniel Salmon who isolated the first organism, Salmonella choleraesuis, from the intestine of a pig. The presence of several pathogenicity islands (PAIs) that encode various virulence factors allows Salmonella spp. to colonize and infect host organisms. There are two important PAIs, Salmonella pathogenicity island 1 and 2 (SPI-1 and SPI-2) that encode two different type III secretion systems for the delivery of effector molecules into the host cell that result in internalization of the bacteria which then leads to systemic spread.

Subject: NC_006348:2738425 Burkholderia mallei ATCC 23344 chromosome 1, complete sequence

Lineage: Burkholderia mallei; Burkholderia; Burkholderiaceae; Burkholderiales; Proteobacteria; Bacteria

General Information: This type strain came from a Chinese patient in Burma who had glanders in 1944. Causes glanders in horses. This organism is rarely associated with human infection, and is more commonly seen in domesticated animals such as horses, donkeys, and mules where it causes glanders, a disease first described by Aristotle. The pathogen is host-adapted and is not found in the environment outside of its host. Rapid-onset pneumonia, bacteremia (spread of the organism through the blood), pustules, and death are common outcomes during infection. No vaccine exists for this potentially dangerous organism.