Pre_GI: SWBIT SVG BLASTP

Query: NC_003155:5987000 Streptomyces avermitilis MA-4680, complete genome

Lineage: Streptomyces avermitilis; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (ATCC 31267) was isolated and characterized in 1978 by R. Burg and colleagues from a soil sample collected in Shizuoka Prefecture, Japan. Antibiotic-producing bacterium. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This organism is a well known producer of the anti-parasitic agent avermectin which is widely used to rid livestock of worm and insect infestations and to protect large numbers of people from river blindness in sub-Saharan Africa.

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BLASTP Alignment.txt

Subject: NC_008148:2156873 Rubrobacter xylanophilus DSM 9941, complete genome

Lineage: Rubrobacter xylanophilus; Rubrobacter; Rubrobacteraceae; Rubrobacterales; Actinobacteria; Bacteria

General Information: Cellulose-degrading bacterium. This genus contains two species: Rubrobacter radiotolerans and Rubrobacter xylanophilus. These two species represent the oldest lineage (deepest branch) of the Actinobacteria and are distantly related to Mycobacteria and Streptomycetes. Both species are thermophilic and exhibit high tolerance to radiation. Very little research has been done on these organisms and little is known other than their taxonomic characterization. Rubrobacter xylanophilus was isolated from a thermally polluted industrial runoff in the United Kingdom. Some strains of this species are capable of degrading hemicellulose and xylan (polymers of plant origin), and could play a significant role in the degradation of these compounds in the wood and paper industry as well as in the environment.