Pre_GI: SWBIT SVG BLASTP

Query: NC_003103:919000 Rickettsia conorii str. Malish 7, complete genome

Lineage: Rickettsia conorii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This strain was isolated from a human in South Africa. Causative agent for Rocky Mountain spotted fever. This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, is composed of obligate intracellular pathogens. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. Transovarial transmission (from mother to offspring) occurs in the invertebrate host. This organism causes Rocky Mountain spotted fever which can cause severe damage to the endothelial layer of major organs, including the lungs, heart, kidneys, and skeletal muscle which can result in death.

Subject: NC_005955:947500 Bartonella quintana str. Toulouse, complete genome

Lineage: Bartonella quintana; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: Bartonella quintana str. Toulouse was isolated from human blood in Toulouse, France in 1993. Causative agent of trench fever. This group of alpha proteobacteria are unique among pathogens in that they cause angiogenic lesions. This organism was first identified as the causative agent of louse-born trench fever during World War I. Up to 800 000 were infected in the trenches because of the louse insect vector that was widespread due to poor sanitation. The disease is now found associated with immunocompromized patients, especially HIV patients and homeless alcoholics.