Pre_GI: SWBIT SVG BLASTP

Query: NC_003103:266013 Rickettsia conorii str. Malish 7, complete genome

Lineage: Rickettsia conorii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This strain was isolated from a human in South Africa. Causative agent for Rocky Mountain spotted fever. This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, is composed of obligate intracellular pathogens. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. Transovarial transmission (from mother to offspring) occurs in the invertebrate host. This organism causes Rocky Mountain spotted fever which can cause severe damage to the endothelial layer of major organs, including the lungs, heart, kidneys, and skeletal muscle which can result in death.

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BLASTP Alignment.txt

Subject: NC_015931:71361 Pyrolobus fumarii 1A, complete genome

Lineage: Pyrolobus fumarii; Pyrolobus; Pyrodictiaceae; Desulfurococcales; Crenarchaeota; Archaea

General Information: Environment: Deep sea, Hydrothermal vent, Marine; Isolation: Hydrothermally heated black smoker wall; Temp: Hyperthermophile; Temp: 106C. Pyrolobus fumarii is an obligate chemolithotroph, gaining energy from the oxidation of hydrogen. This organism can grow at temperatures as high as 113 degrees C.