Query: NC_003103:266013 Rickettsia conorii str. Malish 7, complete genome Lineage: Rickettsia conorii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria General Information: This strain was isolated from a human in South Africa. Causative agent for Rocky Mountain spotted fever. This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, is composed of obligate intracellular pathogens. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. Transovarial transmission (from mother to offspring) occurs in the invertebrate host. This organism causes Rocky Mountain spotted fever which can cause severe damage to the endothelial layer of major organs, including the lungs, heart, kidneys, and skeletal muscle which can result in death.
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General Information: Bacteria belonging to the Rhodobacter group are metabolically versatile as they are able to grow using photosynthesis, chemosynthesis, and usually can grow under both anaerobic and aerobic conditions. The most extensively studied bacteria with regards to its photosynthetic capabilities which includes the structure, function and regulation of its photosynthetic membranes, its mechanisms of CO2 and nitrogen fixation, cytochrome diversity and its electron transport systems. It can grow aerobically and anaerobically in the light and anaerobically in the dark. It produces an intracytoplasmic membrane system consisting of membrane invaginations where the light harvesting complexes (LH1 and LH2) and the reaction center are synthesized. Furthermore, it has the ability to detoxify metal oxides and oxyanions and hence has a role in bioremediation.