Pre_GI: SWBIT SVG BLASTP

Query: NC_003103:919000 Rickettsia conorii str. Malish 7, complete genome

Lineage: Rickettsia conorii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This strain was isolated from a human in South Africa. Causative agent for Rocky Mountain spotted fever. This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, is composed of obligate intracellular pathogens. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. Transovarial transmission (from mother to offspring) occurs in the invertebrate host. This organism causes Rocky Mountain spotted fever which can cause severe damage to the endothelial layer of major organs, including the lungs, heart, kidneys, and skeletal muscle which can result in death.

Subject: NC_013169:2147111 Kytococcus sedentarius DSM 20547, complete genome

Lineage: Kytococcus sedentarius; Kytococcus; Dermacoccaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Country: USA; Temp: Mesophile; Temp: 28 - 36C; Habitat: Marine, Skin microflora. Strain DSM 20547, the type strain, is a free-living, nonmotile, Gram-positive bacterium, originally isolated from a marine environment in about 1944. It grows as spherical/coccoid and occurs predominantly in tetrads which can be arranged in cubical packets. It is non-encapsulated and does not form endospores, is strictly aerobic and chemoorganotrophic, requires methionine and other amino acids for growth, and grows well in NaCl at concentrations up to 10% (w/v). This organism is a normal commensal of human skin, however has been implicated in pitted keratolysis, pneumonia, and other opportunistic infections.