Query: NC_003047:3419212 Sinorhizobium meliloti 1021, complete genome Lineage: Sinorhizobium meliloti; Sinorhizobium; Rhizobiaceae; Rhizobiales; Proteobacteria; Bacteria General Information: Streptomycin resistant derivative of strain 2011. Plant symbiotic bacterium. This organism, much like other Rhizobia, forms a symbiotic relationship with a leguminous plant, in this case the alfalfa plant (Medicago sativa). Expression of nodulation genes results in production of a nodulation signal which the plant cell recognizes inducing root nodule formation. The plant cell provides carbon compounds for the bacterium to grow on.
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General Information: This strain was isolated from an infected goat and is pathogenic in humans. Causes brucellosis and undulant fever. They are highly infectious, and can be spread through contact with infected animal products or through the air, making them a potential bioterrorism agent. Once the organism has entered the body, it can become intracellular, and enter the blood and lymphatic regions, multiplying inside phagocytes before eventually causing bacteremia (spread of bacteria through the blood). Virulence may depend on a type IV secretion system which may promote intracellular growth by secreting important effector molecules. This organism is a facultative intracellular bacteria that causes abortion in wild and domestic animals, usually goats or sheep, and undulant fever in humans. Brucellosis is a major health problem in the Mediterranean region and parts of Asia, Africa, and Latin America, where it causes severe economic losses. The disease is transmitted to humans by nonpasteurized milk and milk products or by direct contact with infected animals or carcasses.