Query: NC_003047:2798367 Sinorhizobium meliloti 1021, complete genome Lineage: Sinorhizobium meliloti; Sinorhizobium; Rhizobiaceae; Rhizobiales; Proteobacteria; Bacteria General Information: Streptomycin resistant derivative of strain 2011. Plant symbiotic bacterium. This organism, much like other Rhizobia, forms a symbiotic relationship with a leguminous plant, in this case the alfalfa plant (Medicago sativa). Expression of nodulation genes results in production of a nodulation signal which the plant cell recognizes inducing root nodule formation. The plant cell provides carbon compounds for the bacterium to grow on.
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General Information: Isolated from a patient with fever and lymphadenitis. Chronic granulomatous disease (CGD) is a rare inherited disease of the phagocyte NADPH oxidase system causing defective production of toxic oxygen metabolites, impaired bacterial and fungal killing, and recurrent life-threatening infections. This species was isolated from a 39 year old man with CGD and was shown to be the causal agent of the disease by classical methods. The isolation of this organism is the first known case of a bacterium from the Acetobacteraceae family to be the cause of an invasive human disease.