Query: NC_002978:200878 Wolbachia endosymbiont of Drosophila melanogaster, complete genome Lineage: Wolbachia endosymbiont of Drosophila melanogaster; Wolbachia; Anaplasmataceae; Rickettsiales; Proteobacteria; Bacteria General Information: Wolbachia endosymbiont of Drosophila melanogaster. Fruitfly endosymbiont. This group of bacteria are associated with a variety of invertebrate species, some as pathogens, some in a symbiotic or other type of relationship. Typically these organisms are transmitted maternally from mother to daughter transovarially (through the egg) although these bacteria can affect their hosts reproductive capabilities in order to enhance transmission. The net outcome is the increase of hosts carrying the bacteria in the next generation, thereby increasing transmission. Wolbachia endosymbiont of Drosophila melanogaster is an obligate intracellular endosymbiont of the fruit fly Drosophila melanogaster.
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General Information: This strain is the first isolate of Ehrlichia chaffeensis, which was obtained from a patient on an army base in Arkansas, USA in 1990. Causes disease in humans. This organism is an obligate intracellular pathogen that exists within vacuoles in the cytoplasm of monocytes or granulocytes. Transferred during an insect (tick) bite, it can cause disease in humans (human monocytic ehrlichiosis) and can reside in several other animals and is a problem in immunocompromised patients. The bacterium inhibits phagosome-lysozome fusion as well as programmed cell death (apoptosis) of the host cell, similar to what is observed with Anaplasma phagocytophilum.