Pre_GI: SWBIT SVG BLASTP

Query: NC_002945:1856228 Mycobacterium bovis AF2122/97, complete genome

Lineage: Mycobacterium bovis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection. Causative agent of classic bovine tuberculosis. This genus comprises a number of Gram-positive, acid-fast, rod-shaped aerobic bacteria and is the only member of the family Mycobacteriaceae within the order Actinomycetales. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of classic bovine tuberculosis, but it can also cause the disease in humans, especially if contaminated milk is consumed without prior pasteurization. The Mycobacterium bovis complex is a diverse group of species, serovars and morphotypes that cause tuberculosis-like diseases in animals and humans. Pasteurization of milk is a major preventitive factor in transmission of bovine tuberculosis to humans. However, spreading the disease through milk and dairy products is still a concern in underdeveloped countries where pasteurization is not practiced.

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BLASTP Alignment.txt

Subject: NC_009480:2580429 Clavibacter michiganensis subsp. michiganensis NCPPB 382, complete

Lineage: Clavibacter michiganensis; Clavibacter; Microbacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Phytopathogen that causes bacterial wilt and canker of tomato (Lycopersicon esculentum). This is considered to be the most important bacterial disease of tomato causing substantial economic losses worldwide. Bacteria enter the plant by wounds on root or stem and then find their way into the xylem allowing a massive systemic colonization. The first stage of the disease is characterized by unilateral wilting of leaves. Wilting then spreads to all leaves, canker lesions develop on the stem and the plant dies. If infection occurs at a late stage of plant development, plants can survive and yield fruit that may have spots, so called bird's eyes. Often the seeds will be infected and this has been the major source for outbreaks of Clavibacter michiganensis subsp. michiganensis infections in agriculture. Members of the Clavibacter genus are known to produce antimicrobial compounds.