Query: NC_002940:919175 Haemophilus ducreyi 35000HP, complete genome Lineage: Haemophilus ducreyi; Haemophilus; Pasteurellaceae; Pasteurellales; Proteobacteria; Bacteria General Information: This strain is a human passage derivative of Haemophilus ducreyi strain 35000 that is serum-resistant. Causative agent of chancroid. A group of organisms that are either obligate parasites or commensal organisms found in animal mucous membranes. Almost all species require the presence of important growth factors found in the blood of their hosts, including either X factor (protoporphyrin IX or heme) or V factor (nicotinamide adenine dinucleotide (NAD or NADP)). This organism is an obligate human pathogen that causes the sexually transmitted disease chancroid (ulcer of the genital region) and it enhances the transmission of HIV (which enhances Haemophilus ducreyi transmission in turn). This organism is an apparent extracellular pathogen that resists phagocytosis. Some of the virulence factors include an outer membrane serum resistance protein, as well as two toxins, cytolethal distending toxin (CDT) and hemolysin, both of which contribute to tissue destruction.
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General Information: Pasteurella multocida subsp. multocida str. Pm70 was isolated in 1995 from a case of fowl cholera in chickens. Pathogen in humans, swine and poultry. This organism was one of the first pathogens ever sudied, and is named after Louis Pasteur, who used it in his vaccination studies in the 1880s. This organism usually resides in the mucous membranes of the intestinal, genital, and respiratory tissues and is an opportunistic pathogen that causes cholera in fowl, bovine hemorrhagic septicemia, and porcine atrophic rhinitis. Collectively these diseases cause millions of dollars in lost livestock every year. The organism can also infect humans if they are bitten by dogs and cats, which are carriers of the organism, but which are asymptomatic. This organism also expresses a hydrophilic capsule that inhibits phagocytosis and complemented-mediated attack.