Pre_GI: SWBIT SVG BLASTP

Query: NC_002932:2142000 Chlorobium tepidum TLS, complete genome

Lineage: Chlorobaculum tepidum; Chlorobaculum; Chlorobiaceae; Chlorobiales; Chlorobi; Bacteria

General Information: This green-sulfur bacterium is a thermophile and was isolated from a New Zealand high-sulfide hot spring. Photosynthetic thermophile. Chlorobium tepidum is a member of the green-sulfur bacteria. It has been suggested that the green-sulfur bacteria were among the first photosynthetic organisms since they are anaerobically photosynthetic and may have arisen early in the Earth's history when there was a limited amount of oxygen present. This organism utilizes a novel photosynthetic system, and harvests light energy using an unusual organelle, the chlorosome, which contains an aggregate of light-harvesting centers surrounded by a protein-stabilized galactolipid monolayer that lies at the inner surface of the cytoplasmic membrane. Unlike many other photosynthetic organisms, the green-sulfur bacteria do not produce oxygen and tolerate only low levels of the molecule. This organism also fixes carbon dioxide via a reverse tricarboxylic acid cycle, using electrons derived from hydrogen or reduced sulfur to drive the reaction, instead of via the Calvin cycle like many other photosynthetic organisms.

Subject: NC_003317:190975 Brucella melitensis 16M chromosome I, complete sequence

Lineage: Brucella melitensis; Brucella; Brucellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: This strain was isolated from an infected goat and is pathogenic in humans. Causes brucellosis and undulant fever. They are highly infectious, and can be spread through contact with infected animal products or through the air, making them a potential bioterrorism agent. Once the organism has entered the body, it can become intracellular, and enter the blood and lymphatic regions, multiplying inside phagocytes before eventually causing bacteremia (spread of bacteria through the blood). Virulence may depend on a type IV secretion system which may promote intracellular growth by secreting important effector molecules. This organism is a facultative intracellular bacteria that causes abortion in wild and domestic animals, usually goats or sheep, and undulant fever in humans. Brucellosis is a major health problem in the Mediterranean region and parts of Asia, Africa, and Latin America, where it causes severe economic losses. The disease is transmitted to humans by nonpasteurized milk and milk products or by direct contact with infected animals or carcasses.