Query: NC_002928:1351750 Bordetella parapertussis 12822, complete genome Lineage: Bordetella parapertussis; Bordetella; Alcaligenaceae; Burkholderiales; Proteobacteria; Bacteria General Information: This strain was isolated from an infected infant in Germany in 1993. Causes respiratory illness in humans and sheep. This group of organisms is capable of invading the respiratory tract of animals and causing severe diseases. They express a number of virulence factors in order to do this including filamentous hemagglutins for attachment, cytotoxins, and proteins that form a type III secretion system for transport of effector molecules into host cells. Bordetella parapertussis can infect humans and sheep and it is unable to persist in the environment. This organism causes a respiratory disease similar to, but less severe than, Bordetella pertussis in humans and a chronic pneumonia in sheep.
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General Information: Sorangium cellulosum 'So ce 56' produces a large number of bioactive compounds, such as, the antifungal soraphen and the anticancer agent epothilone. This organism, like other myxobacteria, undergoes a complex development and differentiation pathway. When cell density increases, the organism switches to "social motility" where aggregates of cells can gather together into masses termed fruiting bodies that may consist of up to 100 000 cells. The motility system is not dependent on flagella like most bacteria, but instead relies on twitching pili: short extracellular appendages that may function analogously to oars in a rowboat. The myxobacteria have proved to be a rich source of novel natural products. Sorangium cellulosum produces a number of antibacterial, antifungal and cytotoxic substances which are being studies for therapeutic applications.