Query: NC_002927:3716894 Bordetella bronchiseptica RB50, complete genome Lineage: Bordetella bronchiseptica; Bordetella; Alcaligenaceae; Burkholderiales; Proteobacteria; Bacteria General Information: This strain was isolated from a rabbit. Causes a respiratory illness in animals. This group of organisms is capable of invading the respiratory tract of animals and causing severe diseases. They express a number of virulence factors in order to do this including filamentous hemagglutinins for attachment, cytotoxins, and proteins that form a type III secretion system for transport of effector molecules into host cells. Bordetella bronchiseptica, which is one of the few Bordetella that is capable of persisting in the environment, is rarely found in humans and is often associated with animals. This organism cause respiratory disease most commonly in pigs, rabbits and dogs.
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General Information: This organism is unique in that it is a bacteriolytic microbe that preys on other gram negative bacteria. It is found throughout soil, sewage, and aquatic environments, and is often associated with biofilms. This organism has a biphasic lifestyle which consists of a free living and motile phase, and an attack phase where the bacterium attaches to a host cell, burrows into the periplasm, and begins to degrade the host from the inside out. The organism sheds its flagellum once it makes irreversible contact with the host, and when it is inside, begins to form a bdelloplast, resulting in degradation of the host cell inner membrane and alteration of its peptidoglycan layer, resulting in a spherical cell. The Bdellovibrio cell elongates until it forms a long coiled structure which then divides, forming many flagellated progeny which continue the degradation of the host cell to propagate the life cycle. The genome encodes a large number of degradative and lytic enzymes which are used to degrade the host organism. The organism has numerous deficiencies in its amino acid biosynthetic pathways, suggesting it utilizes prey metabolites for protein synthesis.