Query: NC_000963:1024000 Rickettsia prowazekii str. Madrid E, complete genome Lineage: Rickettsia prowazekii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria General Information: This strain is an egg-passaged attentuated avirulent strain that has been used as a live vaccine and was originally isolated from a typhus patient in Madrid. This species is the causal agent of typhus. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. Transovarial transmission (from mother to offspring) occurs in the invertebrate host.
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General Information: Francisella philomiragia subsp. philomiragia ATCC 25017 was isolated from water in the Bear River Refuge in Utah, USA. Causes disease in humans and fish. Francisella philomiragia, formerly Yersinia philomiragia, has been isolated from water, muskrats, fish and humans. F. philomiragia is able to cause an often fatal bacteremia in people with chronic granulomatous disease. This supspecies can also cause pneumonia in near-drowning victims.