Query: NC_000917:1778173 Archaeoglobus fulgidus DSM 4304, complete genome Lineage: Archaeoglobus fulgidus; Archaeoglobus; Archaeoglobaceae; Archaeoglobales; Euryarchaeota; Archaea General Information: This is the type strain (DSM 4304) of the Archaeoglobales, and was isolated from a geothermally heated sea floor at Vulcano Island, Italy. Doubling time is four hours under optimal conditions. The organism is an autotrophic or organotrophic sulfate/sulfite respirer. An additional distinguishing characteristic is blue-green fluorescence at 420 nm. This bacterium is the first sulfur-metabolizing organism to have its genome sequence determined. Growth by sulfate reduction is restricted to relatively few groups of prokaryotes; all but one of these are Eubacteria, the exception being the archaeal sulfate reducers in the Archaeoglobales. These organisms are unique in that they are only distantly related to other bacterial sulfate reducers, and because they can grow at extremely high temperatures. The known Archaeoglobales are strict anaerobes, most of which are hyperthermophilic marine sulfate reducers found in hydrothermal environments. High-temperature sulfate reduction by Archaeoglobus species contributes to deep subsurface oil-well 'souring' by iron sulfide, which causes corrosion of iron and steel in oil-and gas-processing systems.
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General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.