Query: NC_000913:558920 Escherichia coli K12, complete genome Lineage: Escherichia coli; Escherichia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria General Information: This organism was named for its discoverer, Theodore Escherich, and is one of the premier model organisms used in the study of bacterial genetics, physiology, and biochemistry. This enteric organism is typically present in the lower intestine of humans, where it is the dominant facultative anaerobe present, but it is only one minor constituent of the complete intestinal microflora. E. coli, is capable of causing various diseases in its host, especially when they acquire virulence traits. E. coli can cause urinary tract infections, neonatal meningitis, and many different intestinal diseases, usually by attaching to the host cell and introducing toxins that disrupt normal cellular processes.
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General Information: Acidovorax sp. JS42, formerly Pseudomonas sp. JS42, was isolated from nitrobenzene-contaminated sediment and is capable of using 2-nitrotolulene as a sole carbon and energy source. 2-nitrotolulene, a nitroaromatic compound, is used in the manufacture of dyes, pigments and explosives. Nitroaromatic compounds, which contain an aromatic ring with one or more nitro groups attached, are a significant contaminant in industrial soils. Acidovorax sp. JS42 degrades 2-nitrotolulene by first removing the nitro moiety producing 3-methylcatechol. The enzyme involved in this process, 2-nitrotolulene dioxygenase, has been purified and characterized.