Pre_GI: SWBIT SVG BLASTP

Query: NC_000117:581987 Chlamydia trachomatis D/UW-3/CX, complete genome

Lineage: Chlamydia trachomatis; Chlamydia; Chlamydiaceae; Chlamydiales; Chlamydiae; Bacteria

General Information: Isolated from the cervix of an asymptomatic female. Opportunistic pathogen. Bacteria belonging to the Chlamydiales group are obligate intracellular parasites of eukaryotic cells. They are found within vertebrates, invertebrate cells, and amoebae hosts. Chlamydiae are one of the commonest causes of sexually transmitted diseases (STDs) and if left untreated may cause infertility in women. They are transmitted by direct contact or aerosols, and can cause various diseases, while also being able to coexist with the host in an apparently asymptomatic state. This species causes infection that leads to blindness and sexually transmitted diseases in humans. There are 15 serovariants that preferentially cause disease in either the eye or the urogenital tract. The trachoma (infection of the mucous membrane of the eyelids) biovars are noninvasive and can cause blinding trachoma (variants A, B, Ba, and C), or sexually transmitted diseases (variants, D, E, F, G, H, I, J, and K). The lymphogranuloma venereum biovars (variants L1, L2, and L3) can cross the epithelial cells of mucous membranes and then travel through the lymphatic system where they multiply within mononuclear phagocytes found within the lymph nodes. This is a trachoma biovar, serovar D strain.

Subject: NC_012225:2421783 Brachyspira hyodysenteriae WA1, complete genome

Lineage: Brachyspira hyodysenteriae; Brachyspira; Brachyspiraceae; Spirochaetales; Spirochaetes; Bacteria

General Information: Brachyspira hyodysenteriae is the causative agent of swine dysentery, which is a severe mucohemorrhagic diarrheal disease of pigs that has economic significance for pork-producing countries. The bacterium can survive for several weeks in cold moist conditions but not under warm dry conditions. It spreads slowly, building up in numbers as the dose rate of the causal agent builds up in the environment. Pigs that recover develop a low immunity and rarely suffer from the disease again. It can be spread by other organisms (flies, mice, birds and dogs) or external mechanical factors; its main habitat is the porcine cecum and colon. It is chemotactically attracted to mucin which it penetrates with a corkscrew-like motility.