Query: NC_020133:5020500 Mycobacterium liflandii 128FXT, complete genome Lineage: Mycobacterium liflandii; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria General Information: First isolated from a colony of African clawed frogs. This organism causes a fatal systemic disease in frogs often characterized by skin lesions. Mycobacterium liflandii produces a polyketide toxin mycolactone E and two highly antigenic proteins ESAT-6 and CFP-10 which account, in part, for its pathogenicity.
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General Information: Used for the production of BCG vaccine in Japan. Causative agent of classic bovine tuberculosis. This bacterium is the causative agent of classic bovine tuberculosis, but it can also cause the disease in humans, especially if contaminated milk is consumed without prior pasteurization. The Mycobacterium bovis complex is a diverse group of species, serovars and morphotypes that cause tuberculosis-like diseases in animals and humans. Pasteurization of milk is a major preventitive factor in transmission of bovine tuberculosis to humans. However, spreading the disease through milk and dairy products is still a concern in underdeveloped countries where pasteurization is not practiced. The pathology in cows is similar to the pathology of Mycobacterium tuberculosis in humans, with pulmonary TB leading to chronic debilitation, coughing, and further systemic spread to other organs. In addition, 1 to 2% of infected cows develop mycobacterial mastitis that results in shedding of the bacteria into the milk.