Pre_GI: SWBIT SVG BLASTN

Query: NC_019673:8763773 Saccharothrix espanaensis DSM 44229 complete genome

Lineage: Saccharothrix espanaensis; Saccharothrix; Pseudonocardiaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Glycosylate natural products. Producer of the saccharomicins, a new class of heptadecaglycoside antibiotics with activity against MRSA and VRE.

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BLASTN Alignment.txt

Subject: NC_010120:2055803 Neisseria meningitidis 053442, complete genome

Lineage: Neisseria meningitidis; Neisseria; Neisseriaceae; Neisseriales; Proteobacteria; Bacteria

General Information: Causes septicemia and meningitis. The second of two pathogenic Neisseria, this organism causes septicemia and is the leading cause of life-threatening meningitis (inflammation of the meninges, the membrane surrounding the brain and spinal cord) in children. This organism typically residies in the nasopharynx cavity but can invade the respiratory epthelial barrier, cross into the bloodstream and the blood brain barrier, and cause inflammation of the meninges. Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). This organism, like Neisseria gonorrhoeae, is naturally competent, and protein complexes at the cell surface recognize the uptake signal sequence in extracellular DNA, an 8mer that is found at high frequency in Neisseria chromosomal DNA.