Pre_GI: SWBIT SVG BLASTN

Query: NC_017516:917817 Neisseria meningitidis H44/76 chromosome, complete genome

Lineage: Neisseria meningitidis; Neisseria; Neisseriaceae; Neisseriales; Proteobacteria; Bacteria

General Information: The second of two pathogenic Neisseria, this organism causes septicemia and is the leading cause of life-threatening meningitis (inflammation of the meninges, the membrane surrounding the brain and spinal cord) in children. This organism typically residies in the nasopharynx cavity but can invade the respiratory epthelial barrier, cross into the bloodstream and the blood brain barrier, and cause inflammation of the meninges. Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). This organism, like Neisseria gonorrhoeae, is naturally competent, and protein complexes at the cell surface recognize the uptake signal sequence in extracellular DNA, an 8mer that is found at high frequency in Neisseria chromosomal DNA.

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BLASTN Alignment.txt

Subject: NC_008390:987052 Burkholderia cepacia AMMD chromosome 1, complete sequence

Lineage: Burkholderia ambifaria; Burkholderia; Burkholderiaceae; Burkholderiales; Proteobacteria; Bacteria

General Information: Isolated from the rhizosphere of healthy pea plants in Wisconsin, USA, in 1985. Pathogenic in cystic fibrosis patients. These bacteria present great versatility to adapt to diverse environments, and are capable of degrading pollutants in water and soil, and fixing atmospheric nitrogen. This species include strains isolated from cystic fibrosis patients as well as strains with potential use in biocontrol.