Pre_GI: SWBIT SVG BLASTN

Query: NC_017514:761000 Neisseria meningitidis M01-240149 chromosome, complete genome

Lineage: Neisseria meningitidis; Neisseria; Neisseriaceae; Neisseriales; Proteobacteria; Bacteria

General Information: The second of two pathogenic Neisseria, this organism causes septicemia and is the leading cause of life-threatening meningitis (inflammation of the meninges, the membrane surrounding the brain and spinal cord) in children. This organism typically residies in the nasopharynx cavity but can invade the respiratory epthelial barrier, cross into the bloodstream and the blood brain barrier, and cause inflammation of the meninges. Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). This organism, like Neisseria gonorrhoeae, is naturally competent, and protein complexes at the cell surface recognize the uptake signal sequence in extracellular DNA, an 8mer that is found at high frequency in Neisseria chromosomal DNA.

Subject: NC_014733:2201485 Methylovorus sp. MP688 chromosome, complete genome

Lineage: Methylovorus; Methylovorus; Methylophilaceae; Methylophilales; Proteobacteria; Bacteria

General Information: Methylotrophic bacteria are a group of bacteria which are able to grow aerobically at the expense of methanol as the sole source of carbon and energy, and therefore could serve as biocatalysts for the conversion of methanol to commercially valuable multicarbon compounds like amino acids and cytochromes. Pink-pigmented facultative methylotrophs of the genus Methylovorus are ubiquitous in soil, air and water environments. The MP688 strain was isolated from soil as an PQQ producer.