Query: NC_017514:2096452 Neisseria meningitidis M01-240149 chromosome, complete genome Lineage: Neisseria meningitidis; Neisseria; Neisseriaceae; Neisseriales; Proteobacteria; Bacteria General Information: The second of two pathogenic Neisseria, this organism causes septicemia and is the leading cause of life-threatening meningitis (inflammation of the meninges, the membrane surrounding the brain and spinal cord) in children. This organism typically residies in the nasopharynx cavity but can invade the respiratory epthelial barrier, cross into the bloodstream and the blood brain barrier, and cause inflammation of the meninges. Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). This organism, like Neisseria gonorrhoeae, is naturally competent, and protein complexes at the cell surface recognize the uptake signal sequence in extracellular DNA, an 8mer that is found at high frequency in Neisseria chromosomal DNA.
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General Information: This strain was isolated from sediment contaminated with cis-dichloroethane (cDCE), a common pollutant resulting from widespread manufacture and use of industrial solvents. This bacterium is the only known organism capable of using cDCE as a sole carbon and energy source. The ability of this strain to convert ethene to epoxyethane suggests that the first step in the cDCE biodegradation pathway is the oxidation of cDCE to an epoxide compound. Bacteria that are able to grow on cDCE are rare, and have only been found in very few highly selective artificial environments. The discovery of this bacteria may provide a low cost, self-sustaining bioremediation method in areas where cDCE is a problem contaminant.