Pre_GI: SWBIT SVG BLASTN

Query: NC_017328:2785309 Shigella flexneri 2002017 chromosome, complete genome

Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining.

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BLASTN Alignment.txt

Subject: NC_014500:894136 Dickeya dadantii 3937 chromosome, complete genome

Lineage: Dickeya dadantii; Dickeya; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Strain 3937 is a wild-type strain isolated from Saintpaulia ionantha plants in the early 1980s. Dickeya dadantii formerly (Erwinia chrysanthemi) is a phytopathogenic bacterium that causes soft rot diseases on many crops. This organism produces pectinolytic enzymes which break down plant cell walls allowing for the spread of disease.