Query: NC_017294:327433 Candidatus Arthromitus sp. SFB-mouse-Yit, complete genome
Lineage: Arthromitus; Arthromitus; Clostridiaceae; Clostridiales; Firmicutes; Bacteria
General Information: Candidatus Arthromitus sp. isolated from BALB/c mouse. Segmented filamentous bacteria isolated from mouse.
Subject: NC_007797:1016456 Anaplasma phagocytophilum HZ, complete genome
Lineage: Anaplasma phagocytophilum; Anaplasma; Anaplasmataceae; Rickettsiales; Proteobacteria; Bacteria
General Information: Isolated from a patient in New York, USA, in 1995. This organism is a tick-borne (Ixodesspp.) obligate intracellular pathogen that infects humans and causes human granulocytic anaplasmosis as well as infecting several other types of animals. This organism produces a number of pathogenic factors that aid virulence. These include specific adhesins for neutrophils, virulence factors that inhibit both phagosome-lysozome fusion and production of reactive oxygen species that would normally kill the bacterium. The bacterium also inhibits programmed cell death of the neutrophil (apoptosis) and induces expression of interleukin-8, which causes neutrophil chemotaxis, thereby increasing the spread of the bacterium throughout the host organism.