Pre_GI: SWBIT SVG BLASTN

Query: NC_017253:155170 Buchnera aphidicola str. JF99 (Acyrthosiphon pisum) chromosome,

Lineage: Buchnera aphidicola; Buchnera; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: It is believed that the Buchnera provide the essential nutrients the host lacks. Besides a nutritional co-dependence, due to a co-existence of millions of years, Buchnera have lost the ability to produce cell surface components such as lipopolysaccharides. This makes for an obligate endosymbiont relationship between host and Buchnera. Buchnera are prokaryotic cells which belong to the gamma-Proteobacteria, closely related to the Enterobacteriaceae family. Phylogenetic studies using 16S rRNA indicate that the symbiotic relationship was established around 200-250 million years ago. Since Buchnera are closely related to Escherichia coli and Haemophilus influenzae, comparative genomic studies can shed light on the evolutionary mechanisms of intracellular endosymbiosis as well as the different underlying molecular basis between organisms with parasitic behavior and symbionts.

Subject: NC_010554:1871000 Proteus mirabilis HI4320, complete genome

Lineage: Proteus mirabilis; Proteus; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Proteus mirabilis is a tetracycline resistant human urinary tract isolate. This bacterium is part of the normal gut flora of a healthy individual, but is also an opportunistic pathogen. Flagellar movement allows this organism to travel through the urinary tract into the bladder and kidney where it may cause infection or stones. Cell death is caused by hemolysin, a pore-forming toxin which disrupts osmotic balance across the host cell membrane. This species is inherently resistant to nitrofuran and tetracycline, and some strains have recently become resistant to ampicillin and trimethoprin.