Pre_GI: SWBIT SVG BLASTN

Query: NC_017246:528825 Brucella melitensis M5-90 chromosome chromosome I, complete

Lineage: Brucella melitensis; Brucella; Brucellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: They are highly infectious, and can be spread through contact with infected animal products or through the air, making them a potential bioterrorism agent. Once the organism has entered the body, it can become intracellular, and enter the blood and lymphatic regions, multiplying inside phagocytes before eventually causing bacteremia (spread of bacteria through the blood). Virulence may depend on a type IV secretion system which may promote intracellular growth by secreting important effector molecules. This organism is a facultative intracellular bacteria that causes abortion in wild and domestic animals, usually goats or sheep, and undulant fever in humans. Brucellosis is a major health problem in the Mediterranean region and parts of Asia, Africa, and Latin America, where it causes severe economic losses. The disease is transmitted to humans by nonpasteurized milk and milk products or by direct contact with infected animals or carcasses.

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BLASTN Alignment.txt

Subject: NC_004842:1132441 Anaplasma marginale str. St. Maries, complete genome

Lineage: Anaplasma marginale; Anaplasma; Anaplasmataceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This strain was recovered from an acutely infected cow from Northern Idaho, USA and bears an msp1a genotype of JBB. This strain is transmitted by ticks and is known to be virulent. This organism is the causative agent of bovine anaplasmosis and is an obligate intracellular pathogen. Transmission occurs via an arthropod vector (tick) and is a major problem in tropical regions where it causes severe morbidity in cattle populations. The bacterium lives intracellularly within membrane-bound vesicles in the host erythrocyte, a cell type which it specifically targets, resulting in severe anemia for the host organism.