Pre_GI: SWBIT SVG BLASTN

Query: NC_017244:264921 Brucella melitensis M28 chromosome chromosome 1, complete sequence

Lineage: Brucella melitensis; Brucella; Brucellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: They are highly infectious, and can be spread through contact with infected animal products or through the air, making them a potential bioterrorism agent. Once the organism has entered the body, it can become intracellular, and enter the blood and lymphatic regions, multiplying inside phagocytes before eventually causing bacteremia (spread of bacteria through the blood). Virulence may depend on a type IV secretion system which may promote intracellular growth by secreting important effector molecules. This organism is a facultative intracellular bacteria that causes abortion in wild and domestic animals, usually goats or sheep, and undulant fever in humans. Brucellosis is a major health problem in the Mediterranean region and parts of Asia, Africa, and Latin America, where it causes severe economic losses. The disease is transmitted to humans by nonpasteurized milk and milk products or by direct contact with infected animals or carcasses.

Subject: NC_010554:2789722 Proteus mirabilis HI4320, complete genome

Lineage: Proteus mirabilis; Proteus; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Proteus mirabilis is a tetracycline resistant human urinary tract isolate. This bacterium is part of the normal gut flora of a healthy individual, but is also an opportunistic pathogen. Flagellar movement allows this organism to travel through the urinary tract into the bladder and kidney where it may cause infection or stones. Cell death is caused by hemolysin, a pore-forming toxin which disrupts osmotic balance across the host cell membrane. This species is inherently resistant to nitrofuran and tetracycline, and some strains have recently become resistant to ampicillin and trimethoprin.